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The areca nut is the seed of the areca palm (Areca catechu), which grows in much of the tropical Pacific, Asia, and parts of east Africa. It is commonly referred to as betel nut, as it is often chewed wrapped in betel leaves (paan). The habit has many harmful effects on health. The International Agency for Research on Cancer concluded that chewing areca nut is carcinogenic to humans after reviewing the published medical research. Various compounds present in the nut, most importantly arecoline, contribute to histologic changes in the oral mucosa. As with chewing tobacco, its use is discouraged by preventive efforts. Black pepper (Piper nigrum) is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit, known a
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